Phytoestrogens as Therapeutic Alternatives
نویسندگان
چکیده
Epidemiologic data illustrate strong associations between diets high in foods containing phytoestrogens and a reduction in coronary heart disease (CHD), breast and other cancers, and menopausal symptoms. However, controlled clinical trials that encourage health care providers to endorse phytoestrogens as an alternative to conventional hormone replacement therapy (HRT) in postmenopausal women are lacking. Most data that support or refute widespread use of phytoestrogens come from animal and epidemiologic human studies. In comparison, controlled clinical trials have assessed the effects of conventional HRT on CHD risk factors and osteoporosis by changes in bone mineral density (BMD). 2 Cohort studies in humans identified the role of HRT in breast cancer risk. Epidemiologic studies further illustrated the relationship with breast cancer as well as effects of HRT on overall mortality. In addition to limited clinical trial data on the efficacy of phytoestrogens, the following questions are unanswered:
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